Basic Information
VIS ID
TVIS10009072
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1803
Orient
-
Integrated sequence
CATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTG| |CGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCA
Host Sequence
Chromosome
chr5
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
98979926/99644222 (Hg38)
End
98979926/99644222 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA5F
Nearest miRNA
hsa-mir-10397/Upstream/3565010; hsa-mir-103a-1/Downstream/1172260;
Nearest TSS
ENST00000502646/Upstream/94790; ENST00000511468/Downstream/757219;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/714395, chr5-CpG: 62/Downstream/890999
Nearby gene
LOC100289230(-713213) ; LOC100133050(+735283) ;
Upstream sequence
TAAAAGAACCATTTTTCTCGTATATTTCTATTGACGAAGGTAATGTATTAAACTTGTTGAATAACCTTAAATAGCAGTCAAATGTGGACTTGGTGGATTT
Downstream sequence
cgtcaaaaaaaaaaaaaaaaaaaaGAGGTTGTTGATAATATTTAATGCAGCAAATTTAATTATATGCTATAAGAGGACTAGGGTGATATGGAGAGAAGAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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