Basic Information
VIS ID
TVIS10009075
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1850
Orient
+
Integrated sequence
GAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTG| |TTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTC
Host Sequence
Chromosome
chr6
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
48296892/48329156 (Hg38)
End
48296892/48329156 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10398/Upstream/3131386; hsa-mir-10524/Downstream/3815193;
Nearest TSS
ENST00000381078/Upstream/260467; ENST00000335783/Downstream/1134035;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/260262, chr6-CpG: 20/Downstream/1134065
Nearby gene
PTCHD4(-260467) ; MUT(+1101181) ;
Upstream sequence
AATCCTTAAGTAGCTTTATACTGCACAAATGTTTGAGAGTTAGAGGTGAAGTGCTCgagtcaaacagacacgcattcagtttctgccccgtcactcgccg
Downstream sequence
CCACTTTCAATACTTTCTTTATCTTCTTAGCATATCTTTGTTAAACTGCTCTAATGGGGCTGCCCTTGGCTGTTTAAAACATCTACATCCTTCTCTGAAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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