Basic Information
VIS ID
TVIS10009083
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1802
Orient
-
Integrated sequence
GCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCT| |GCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGC
Host Sequence
Chromosome
chrX
Cytoband
q25
Reference genome
GRCh37/hg19
Start
122925868/123792018 (Hg38)
End
122925868/123792018 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7f-2/Upstream/2420965; hsa-mir-105-1/Downstream/10377360;
Nearest TSS
ENST00000429181/Upstream/58962; ENST00000422098/Downstream/67706;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/58771, chrX-CpG: 62/Downstream/67810
Nearby gene
THOC2(-58964) ; XIAP(+67794) ;
Nearest cancer related gene
XIAP(OG, +67794) ;
Upstream sequence
agaacagtatgggggcactacccccatgattcaattatctcccaccgggtctctcccacaatatgtgggaattatgggaactataattcaagatgagatt
Downstream sequence
ctcgtgatccacccgcctcagcctcccaaagtgctgggattacaggcgtgagccaccgcaccccgccTTGAGTGGATTCTTGATCCACATTGCACACTTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate