Basic Information
VIS ID
TVIS10009087
Fusion event
HBV-chr14 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1818
Orient
-
Integrated sequence
GTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATG| |CAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTT
Host Sequence
Chromosome
chr14
Cytoband
q32.2
Reference genome
GRCh37/hg19
Start
99038674/98572337 (Hg38)
End
99038674/98572337 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1260a/Upstream/3434351; hsa-mir-1185-1/Downstream/1537082;
Nearest TSS
ENST00000550708/Upstream/75205; ENST00000546029/Downstream/139276;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/1352728, chr14-CpG: 53/Downstream/545731
Nearby gene
LINC01550(-594213) ; C14orf177(+139276) ;
Upstream sequence
agccttgttgcctcatggttctaagatggctacaacagctctaaggatcatatcttcacacaagcagagtcaaagatagaaagaaagAGATGACCAGGGT
Downstream sequence
GGTGAAGAAGAGCTCCCCTCACGAACCTCTTTACTTTTATCAAGGCAGAATTCTCTTTCCTGGGAGCCATTCAATAGGCTTCCCCTTATATTTTATTCTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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