Basic Information
VIS ID
TVIS10009092
Fusion event
HBV-chr20 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
865
Orient
-
Integrated sequence
AGTCTGTACAGCATCTTGAGTCCCTTTTTACCGCTGTTACCAATTTTCTTTTGTCTTTGGGTATACATTTAAACCCTAACAAAACAAAGAGATGGGGTTA| |CTCTCTAAATTTTATGGGTTATGTCATTGGATGTTATGGGTCCTTGCCACAAGAACACATCATACAAAAAATCAAAGAATGTTTTAGAAAACTTCCTATT
Host Sequence
Chromosome
chr20
Cytoband
q13.13
Reference genome
GRCh37/hg19
Start
49118602/50502065 (Hg38)
End
49118602/50502065 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-103a-2/Upstream/638112; hsa-mir-1-1/Downstream/83721;
Nearest TSS
ENST00000382410/Upstream/180723; ENST00000541713/Downstream/8256;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/158229, chr20-CpG: 84/Downstream/8015
Nearby gene
LINC01270(-187146) ; PTPN1(+8289) ;
Nearest cancer related gene
PTPN1(TSG, +8289) ;
Upstream sequence
ACACCCAGAACCACCATGTGTACAGTGAAAGTGCCCCCGCAAGCCTCAGCCCTGCAAACTAGAGTGTGGAGGATGTTGTAGGGGCCTCTGGAAACCCTCC
Downstream sequence
CCAGACTCCTCCTTTGCTGAAAGCATGGAGCTGGGACCGGTTTCCATCTTTGGATCCAACTTCCCTCCTTGAACTTTCCCGCACATCTCTGACCCTCCTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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