Basic Information
VIS ID
TVIS10009093
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1775
Orient
-
Integrated sequence
TCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTAC| |TAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCC
Host Sequence
Chromosome
chr3
Cytoband
p14.1
Reference genome
GRCh37/hg19
Start
66604323/66553899 (Hg38)
End
66604323/66553899 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7g/Upstream/5936029; hsa-mir-12124/Downstream/671565;
Nearest TSS
ENST00000440867/Upstream/52636; ENST00000460784/Downstream/444408;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/52475, chr3-CpG: 81/Downstream/444132
Nearby gene
LRIG1(-53478) ; KBTBD8(+444404) ;
Nearest cancer related gene
LRIG1(TSG, -53478) ;
Upstream sequence
TATTGGTGGGTACAGATCATATTCTCCAGTTTTCATAGCCATAATTGTGGCAATGAAACATTTCAGAGAAACATAACAAACACAAAAAAAGTACAGATGT
Downstream sequence
gggagggggcaggggcgggtgctgcagtggatgcatagcttgagcctgggaggttgaagcttcagtgaactgattgctccgccgcactccagcctgggtg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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