Basic Information
VIS ID
TVIS10009095
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1765
Orient
-
Integrated sequence
TCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAG| |GTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGT
Host Sequence
Chromosome
chr5
Cytoband
q35.3
Reference genome
GRCh37/hg19
Start
176539895/177112894 (Hg38)
End
176539895/177112894 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA5G
Nearest miRNA
hsa-mir-10397/Upstream/483394; hsa-mir-1229/Downstream/2685384;
Nearest TSS
ENST00000502646/Upstream/15703; ENST00000512992/Downstream/20131;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/19273, chr5-CpG: 35/Downstream/4005
Nearby gene
FGFR4(-14769) ; NSD1(+20185) ;
Nearest cancer related gene
FGFR4(OG, -14769) ; NSD1(OG, +20185) ;
Upstream sequence
TGTATAGCCTCTGCACAGAAAATAAAAAAATAAAATGAAGCTTGCCTTTTTACTATTGCACAAAAAAGAATTGGGAAGTCATCATGAAATGTGAGCATAT
Downstream sequence
CTGAGCTGGGGCTCCCAGTCCTGTCTCCAGTCTTTCTGGGCTAGACAGGGGCAGCCCTGCAAGGTGCCAGCCTAATTCCTCTGCCTGACCTCCCTGAGGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate