Basic Information
VIS ID
TVIS10009097
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1830
Orient
+
Integrated sequence
ACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCAC| |CTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTG
Host Sequence
Chromosome
chr8
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
97429197/96416969 (Hg38)
End
97429197/96416969 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA8B
Nearest miRNA
hsa-mir-12123/Upstream/1343973; hsa-mir-10400/Downstream/1976676;
Nearest TSS
ENST00000518652/Upstream/29531; ENST00000520233/Downstream/76382;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/154430, chr8-CpG: 160/Downstream/76550
Nearby gene
PTDSS1(-82423) ; SDC2(+76685) ;
Upstream sequence
CAGAGGAAGAGGGGGCATGAATGGCTAGAAAAGCAATGATGAGGGTACTTGGGATTTTTTTTCTGGCCACCCCTTCACTGGCACAGAAAATGAAGTGATA
Downstream sequence
CAATCTTCACTTCCGTCCCTTGACAAACATTAAGGGATCAAATGCATAATCCACATCAACACACCTTAAAATACCCTTACCtggagcgatggaagcattt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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