VISDB Viral Integration Site DataBase

VIS ID

TVIS10009099

Fusion event

HBV-THEM4 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|Polymerase|

Start

2384

Orient

+

Integrated sequence

CTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCC| |CTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTT

Chromosome

chr1

Cytoband

q21.3

Reference genome

Start

End

151864697/151892221 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-30a-5p ; hsa-mir-16-5p ; hsa-mir-8057 ; hsa-mir-6749-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-4772-3p ; hsa-mir-1236-3p ; hsa-mir-1304-3p ; hsa-mir-877-3p ; hsa-mir-660-3p ; hsa-mir-5193 ; hsa-mir-6890-3p ; hsa-mir-5089-5p ; hsa-mir-5589-5p ; hsa-mir-4731-5p ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-7107-5p ; hsa-mir-1234-3p ; hsa-mir-5009-3p ; hsa-mir-512-3p ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-4796-3p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p ; hsa-mir-3609 ; hsa-mir-548ah-5p

Nearest miRNA

hsa-mir-101-1/Upstream/346330; hsa-mir-1182/Downstream/1797484;

Nearest TSS

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/52172, chr1-CpG: 66/Downstream/17066

Upstream sequence

tgggtagcaaagaggaTCTCAAACTCCTCTTGATTCTGAGAGGGTCAAATTTTAGTCAAGAGCGAATGAGGGTTGGATGAAGAAATGAGCAAAATGTAGG

Downstream sequence

AATGGAACCCTGGAAAACATTGACATTTAAGGAGCAAGTAGAAGGAGGAGGGAAGATTGGTCTGAAAGGTTTAtgaaagccaaaagaaaatgtttcaatg