Basic Information
VIS ID
TVIS10009101
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1826
Orient
-
Integrated sequence
AAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTT| |TCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAA
Host Sequence
Chromosome
chr1
Cytoband
q32.1
Reference genome
GRCh37/hg19
Start
199731400/199762272 (Hg38)
End
199731400/199762272 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/903119; hsa-mir-1182/Downstream/1957236;
Nearest TSS
ENST00000473358/Upstream/613674; ENST00000447034/Downstream/265330;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/1603038, chr1-CpG: 36/Downstream/273074
Nearby gene
MIR181A1HG(-824842) ; NR5A2(+265370) ;
Upstream sequence
TACCTTGTTTCTATAGCTACTAATAGCAGAGCTACCCTCAAAACTATAATGGAGTTTGCCTCTCCTATTCTTATTTTAAAGAAAATAGAAAATTGAGTAC
Downstream sequence
TTTAAAACTTAGTGAATTTCTGCTTTTTAATTGCTCTGCTTCTGATGGAAAATCCACTTTACCCTACCTGATTTTATATCACTGGAAATGGGACTGGCAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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