Basic Information
VIS ID
TVIS10009104
Fusion event
HBV-HSD52 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1791
Orient
-
Integrated sequence
CCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCA| |TAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGT
Host Sequence
Chromosome
chr1
Cytoband
p32.1
Reference genome
GRCh37/hg19
Start
59605186/59139514 (Hg38)
End
59605186/59139514 (Hg38)
Orient
-
Location type
ncRNA_intronic
Fragile sites / regions
FRA1B
Target gene
HSD52
Nearest miRNA
hsa-mir-12136/Upstream/3913791; hsa-mir-101-1/Downstream/593713;
Nearest TSS
ENST00000473358/Upstream/7041; ENST00000583635/Downstream/150126;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/235286, chr1-CpG: 39/Downstream/7221
Upstream sequence
TGGCCTCAGAGAGGGGAAGAGACGCCCCTTGAGATAGACAGGCAAACTCAGGTAGAGCGGAAGGCAGGGAAACTCACTCTCAGTGACTCAGCAGCCCAGC
Downstream sequence
CCACTGTCTGGCCTTTTCCCCATATCACTGATATCTACTGAAAGGGTGATCCCTGCTTGTGTCCTGAAGCCCCAGGGGTAAGTGGCAACCTGAGTCACAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate