VISDB Viral Integration Site DataBase

VIS ID

TVIS10009106

Fusion event

HBV-ARMH3 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1823

Orient

-

Integrated sequence

TTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACT| |TTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAA

Chromosome

chr10

Cytoband

q24.32

Reference genome

Start

End

103717259/101957502 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

FRA10D ; FRA10A ; FRA10B

Target gene

miRNAs that regulate target gene

hsa-mir-6745 ; hsa-mir-363-5p ; hsa-mir-555 ; hsa-mir-608 ; hsa-mir-4651 ; hsa-mir-7110-5p ; hsa-mir-6842-5p ; hsa-mir-6752-5p ; hsa-mir-761 ; hsa-mir-3619-5p ; hsa-mir-214-3p ; hsa-mir-6510-5p ; hsa-mir-6732-5p ; hsa-mir-3936 ; hsa-mir-4520-3p ; hsa-mir-6721-5p ; hsa-mir-6860 ; hsa-mir-5189-5p ; hsa-mir-612 ; hsa-mir-3187-5p ; hsa-mir-1285-3p ; hsa-mir-4638-3p ; hsa-mir-922 ; hsa-mir-10b-3p ; hsa-mir-6501-3p ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-7977 ; hsa-mir-7154-5p ; hsa-mir-6748-5p ; hsa-mir-6769b-5p ; hsa-mir-6769a-5p ; hsa-mir-3165 ; hsa-mir-4483 ; hsa-mir-1293 ; hsa-mir-6766-5p ; hsa-mir-6756-5p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-4680-5p ; hsa-mir-8060 ; hsa-mir-383-3p ; hsa-mir-4761-5p ; hsa-mir-1273e ; hsa-mir-1827 ; hsa-mir-3929 ; hsa-mir-4419b ; hsa-mir-4478 ; hsa-mir-4649-3p ; hsa-mir-4722-5p ; hsa-mir-4768-3p ; hsa-mir-485-5p ; hsa-mir-658 ; hsa-mir-665 ; hsa-mir-6808-5p ; hsa-mir-6840-3p ; hsa-mir-6884-5p ; hsa-mir-6893-5p ; hsa-mir-7160-5p ; hsa-mir-7846-3p ; hsa-mir-940

Nearest miRNA

hsa-mir-107/Upstream/356005; hsa-mir-1307/Downstream/479010;

Nearest TSS

Nearest CpG islands

None/Target, chr10-CpG: 68/Upstream/113833, chr10-CpG: 72/Downstream/98243

Upstream sequence

CAGAGATCTAACCTATACCCACCCCTGCCAGACAATATATTTTCATGAAGGAAAGAGAGTCATGCAGAGTTTGCCAAAGACATAGGTGAGAGTGGGGACC

Downstream sequence

ACCAGTCCAGATTCGGATCCAAAAAATATATATAGGTCTGGTTCCCTCTATGGCTTAGTCCCCAGACCACCAGCTCCTGTTTCAAACCAGTGCATTTCTG