Basic Information
VIS ID
TVIS10009109
Fusion event
HBV-chr10 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1845
Orient
+
Integrated sequence
GGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATC| |TCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGT
Host Sequence
Chromosome
chr10
Cytoband
q26.12
Reference genome
GRCh37/hg19
Start
121825156/120065644 (Hg38)
End
121825156/120065644 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA10D ; FRA10F ; FRA10A ; FRA10B
Nearest miRNA
hsa-mir-107/Upstream/107052; hsa-mir-202/Downstream/2351321;
Nearest TSS
ENST00000439456/Upstream/124463; ENST00000496437/Downstream/391310;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/53733, chr10-CpG: 109/Downstream/391103
Nearby gene
MIR4682(-107052) ; PLPP4(+391310) ;
Upstream sequence
ctccctttcctaccctactggattattttgaagccaatcccagccatcatctcatttttataggtaagtttggatatctgaaagaaaaggactctatttt
Downstream sequence
ttgtaagcatggctatgacaccattatcactcctaagatactgacagtagtttcctaatattgaacaccttatcaatgttcaagttgccctgattcagat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate