VISDB Viral Integration Site DataBase

VIS ID

TVIS10009112

Fusion event

HBV-chr10 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

2134

Orient

-

Integrated sequence

CCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAG| |ATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGG

Chromosome

chr10

Cytoband

q22.2

Reference genome

Start

End

75002399/73242641 (Hg38)

Orient

+

Location type

downstream

Target gene

DNAJC9 ; FAM149B1

miRNAs that regulate target gene

hsa-mir-193b-3p ; hsa-mir-140-3p ; hsa-mir-103a-3p ; hsa-mir-16-5p ; hsa-mir-615-3p ; hsa-mir-6739-3p ; hsa-mir-4677-5p ; hsa-mir-7156-5p ; hsa-mir-4273 ; hsa-mir-1229-3p ; hsa-mir-2117 ; hsa-mir-342-3p ; hsa-mir-4719 ; hsa-mir-6715a-3p ; hsa-mir-3675-3p ; hsa-mir-216b-5p ; hsa-mir-195-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p

Nearest miRNA

hsa-mir-1265/Upstream/521541; hsa-mir-107/Downstream/2309817;

Nearest TSS

Nearest CpG islands

None/Target, chr10-CpG: 68/Upstream/74491, chr10-CpG: 68/Downstream/4230

Upstream sequence

aaatttggaTTTCACTCTTTGTTTTGATGTAGTAACTCTTTTATAAAAGGGAACAGATTCAGACAAGCTCAGTGGCCCAACTGAAGACATTCAGCAATTA

Downstream sequence

ATGGCAGGACTTCAGTAATCAGTGGCAGGACTACAACATACATCTCTTCATGCTAGGGAAACCAGGCTCTCTATTATAAAGCTGACCAGGGCTATTGTTT