VISDB Viral Integration Site DataBase

VIS ID

TVIS10009116

Fusion event

HBV-IGF1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1802

Orient

+

Integrated sequence

GCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCT| |GCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGC

Chromosome

chr12

Cytoband

q23.2

Reference genome

Start

End

102806421/102412643 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-1-3p ; hsa-mir-27a-3p ; hsa-mir-483-3p ; hsa-let-7e-5p ; hsa-mir-190b ; hsa-mir-299-3p ; hsa-let-7i-5p ; hsa-mir-199a-3p ; hsa-mir-190a-5p ; hsa-mir-29a-3p ; hsa-mir-6739-3p ; hsa-mir-576-5p ; hsa-mir-7156-5p ; hsa-mir-4273 ; hsa-mir-7641 ; hsa-mir-539-5p ; hsa-mir-6516-5p ; hsa-mir-455-3p ; hsa-mir-7847-3p ; hsa-mir-6880-5p ; hsa-mir-6851-5p ; hsa-mir-3689d ; hsa-mir-6499-3p ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-6134 ; hsa-mir-302a-5p ; hsa-mir-6840-3p ; hsa-mir-665 ; hsa-mir-4459 ; hsa-mir-6771-3p ; hsa-mir-1277-5p ; hsa-mir-190a-3p ; hsa-mir-211-3p ; hsa-mir-5011-5p ; hsa-mir-4662a-3p ; hsa-mir-1305 ; hsa-mir-4753-3p ; hsa-mir-421 ; hsa-mir-505-3p ; hsa-mir-7159-5p ; hsa-mir-130b-5p ; hsa-mir-3065-5p ; hsa-mir-10a-3p ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-6514-3p ; hsa-mir-6765-5p ; hsa-mir-7977 ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-7160-5p ; hsa-mir-6847-3p ; hsa-mir-6811-3p ; hsa-mir-214-5p ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-6087 ; hsa-mir-3197 ; hsa-mir-4649-3p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-574-5p ; hsa-mir-297 ; hsa-mir-6867-5p ; hsa-mir-4711-3p ; hsa-mir-223-5p ; hsa-mir-567 ; hsa-mir-133a-3p ; hsa-mir-18b-5p ; hsa-mir-28-5p ; hsa-mir-603 ; hsa-mir-130b-3p ; hsa-mir-98-5p ; hsa-mir-26b-5p ; hsa-mir-129-5p ; hsa-mir-128-3p ; hsa-mir-26a-5p

Nearest miRNA

hsa-let-7i/Upstream/2222694; hsa-mir-1178/Downstream/1517782;

Nearest TSS

Nearest CpG islands

None/Target, chr12-CpG: 104/Upstream/292472, chr12-CpG: 38/Downstream/411699

Nearest cancer related gene

IGF1(TSG, No orient, 0)

Upstream sequence

TTTCTAACCATCATACTTCCACTTTTTAAAAAGTTAGCTTCTTGACCAATGGTTCTTAAAACTATAATCATATTAGTTAAAAAAATAAAGATGGGAATTT

Downstream sequence

CCAAAATGTTTTCTAGCTCCTGTTACTCATCTAACAATAGGCAATGAAAGTTATAATTGAGTTCCTGGTATGATAAGAACTTTCTTAGGGGCTCTCTGGA