Basic Information
VIS ID
TVIS10009119
Fusion event
HBV-chr12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2541
Orient
-
Integrated sequence
ATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATC| |TTTTCCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAGTTAATGAGAAAAGAAGATTGCAATTGATTATG
Host Sequence
Chromosome
chr12
Cytoband
p12.2
Reference genome
GRCh37/hg19
Start
21097483/20944549 (Hg38)
End
21097483/20944549 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1244-3/Upstream/3271155; hsa-let-7i/Downstream/3267872;
Nearest TSS
ENST00000382841/Upstream/82090; ENST00000541784/Downstream/71147;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/391479, chr12-CpG: 34/Downstream/492986
Nearby gene
SLCO1B3(-27640) ; SLCO1B7(+71147) ;
Upstream sequence
agggctttattcagccgggagcttcagcaagactcatgtctgtaaaaactgagctccccaagtgagcaattcctgtcccctttaaggacttacaactcta
Downstream sequence
acagggtccacatgagagtgtcgtgatcaattgagcaagcagggggtacatgactgggggatgcatgcaccgatcatcagagcagaacaggacaggaatt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate