Basic Information
VIS ID
TVIS10009121
Fusion event
HBV-SOX1-OT integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
403
Orient
+
Integrated sequence
GGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCT| |TCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAAC
Host Sequence
Chromosome
chr13
Cytoband
q34
Reference genome
GRCh37/hg19
Start
112641540/111987226 (Hg38)
End
112641540/111987226 (Hg38)
Orient
-
Location type
Intronic
Target gene
SOX1-OT
Nearest miRNA
hsa-mir-1267/Upstream/1646197; hsa-mir-4502/Downstream/1275694;
Nearest TSS
ENST00000623511/Upstream/87238; ENST00000330949/Downstream/80421;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/10744, chr13-CpG: 131/Downstream/27708
Nearby gene
TEX29(-644946) ; SOX1(+80373) ;
Upstream sequence
TACCAGTACAGCCAATATTTTATTTTCTTCATATCCAAACTACAAGAAAATTAAATGCCTGTCTTTATCCAGTACCCTGAATTGACTGAACCTACAAAAG
Downstream sequence
CATTTGAAATCATTAACAAACCTAGATTCTAGCAGGTACTAGAAGCAAAGTTGGCTGCCCCACATCAATAAACTCCAGGATTGAACAGTTGGTTGTTTTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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