Basic Information
VIS ID
TVIS10009126
Fusion event
HBV-LOC105370429 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1789
Orient
-
Integrated sequence
GACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGG| |CATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGG
Host Sequence
Chromosome
chr14
Cytoband
q12
Reference genome
GRCh37/hg19
Start
30402117/29932911 (Hg38)
End
30402117/29932911 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105370429
Nearest miRNA
hsa-mir-208a/Upstream/2299633; hsa-mir-1185-1/Downstream/1081735;
Nearest TSS
ENST00000550708/Upstream/5169; ENST00000553082/Downstream/7834;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/4697, chr14-CpG: 59/Downstream/626016
Nearby gene
PRKD1(-5218) ; G2E3(+626212) ;
Upstream sequence
caacagagcaagactccatctcaaaaaaaacaaaaaaagaaagaaagaaaGAAACCAAATTTCTAGGTATGATCCTAGAGTCAGAGACCCTGAAAGGACA
Downstream sequence
GGAGGCCCTTGAAGAAAAGCTTTCAACTATAAAATCATAAATGATCCAGGTGAGGAATAAATGCAGAAACCAGTGTGACTACACCTCAAGTTTTGGATAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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