Basic Information
VIS ID
TVIS10009127
Fusion event
HBV-LOC105370429 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2038
Orient
+
Integrated sequence
GTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTG| |AGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCC
Host Sequence
Chromosome
chr14
Cytoband
q12
Reference genome
GRCh37/hg19
Start
30402140/29932934 (Hg38)
End
30402140/29932934 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105370429
Nearest miRNA
hsa-mir-208a/Upstream/2299656; hsa-mir-1185-1/Downstream/1081712;
Nearest TSS
ENST00000550708/Upstream/5192; ENST00000553082/Downstream/7811;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/4720, chr14-CpG: 59/Downstream/625993
Nearby gene
PRKD1(-5241) ; G2E3(+626189) ;
Upstream sequence
aaaaaaacaaaaaaagaaagaaagaaaGAAACCAAATTTCTAGGTATGATCCTAGAGTCAGAGACCCTGAAAGGACAGGAGGCCCTTGAAGAAAAGCTTT
Downstream sequence
CAACTATAAAATCATAAATGATCCAGGTGAGGAATAAATGCAGAAACCAGTGTGACTACACCTCAAGTTTTGGATAAGTACAAACAGGCCAAGAAAATGA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate