Basic Information
VIS ID
TVIS10009128
Fusion event
HBV-chr14 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1818
Orient
-
Integrated sequence
GTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATG| |CAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTT
Host Sequence
Chromosome
chr14
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
83224603/82758259 (Hg38)
End
83224603/82758259 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1260a/Upstream/5491969; hsa-mir-1185-1/Downstream/11189967;
Nearest TSS
ENST00000550708/Upstream/115623; ENST00000554753/Downstream/37962;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/1224169, chr14-CpG: 45/Downstream/2771891
Nearby gene
SEL1L(-1224398) ;
Upstream sequence
ACTTTTCTAATTGCAATCAAAATGAAGCTCTGTTTATGTGTGGGAATAACTTGGGCATCAAGACTGCCAGGGATTGAAAGATTCCATACTTTCCTCTTCA
Downstream sequence
GTTTAGAAGCCTATATAGAATCATAACTTTTCTTTCTAAAATGCATGTGTTATTTTCTGATAGAATCCTGGGAGCTGAGGGGGCTGGGGATTGGAAAACA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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