VISDB Viral Integration Site DataBase

VIS ID

TVIS10009130

Fusion event

HBV-GABRB3 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1799

Orient

-

Integrated sequence

GAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGG| |TCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGG

Chromosome

chr15

Cytoband

q12

Reference genome

Start

End

26936398/26691251 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-26b-5p ; hsa-mir-125b-5p ; hsa-let-7g-3p ; hsa-let-7a-2-3p ; hsa-mir-3177-5p ; hsa-mir-3163 ; hsa-mir-5582-3p ; hsa-mir-552-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-3678-3p ; hsa-mir-1273h-3p ; hsa-mir-6802-3p ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-298 ; hsa-mir-6862-3p ; hsa-mir-6784-3p ; hsa-mir-4691-3p ; hsa-mir-497-3p ; hsa-mir-424-3p ; hsa-mir-4703-3p ; hsa-mir-520d-5p ; hsa-mir-524-5p

Nearest miRNA

hsa-mir-1268a/Upstream/842426; hsa-mir-10393/Downstream/1735240;

Nearest TSS

Nearest CpG islands

None/Target, chr15-CpG: 55/Upstream/20645, chr15-CpG: 174/Downstream/80494

Upstream sequence

TGCTCTCCCTGCTCTGTTTTCATTTCTATCTTCTCAAACATCCCTTAGGTTTCTCTTGTTTTTTCCCTCTTTTCCCCTTTTTAATATATGAGTTTTGTAT

Downstream sequence

ATGAGTTTCTATGGTAACATGAAGCAAAGAAATGATTTCTTTATAAATTTCCTGGTACGGAAGGAAAGAACCATCAAGATGCAAAGACGGGGAAGAAAAA