Basic Information
VIS ID
TVIS10009135
Fusion event
HBV-LOC105370956 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1732
Orient
-
Integrated sequence
CCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGAC| |TGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCT
Host Sequence
Chromosome
chr15
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
87945558/87402327 (Hg38)
End
87945558/87402327 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105370956
Nearest miRNA
hsa-mir-10393/Upstream/1576597; hsa-mir-11181/Downstream/543879;
Nearest TSS
ENST00000557528/Upstream/360273; ENST00000560153/Downstream/174602;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/1561443, chr15-CpG: 36/Downstream/853096
Nearby gene
AGBL1(-373275) ; LINC00052(+174602) ;
Upstream sequence
TCATCTTTCGTAGTTGAGCTAGACTTGTCAGTGGAGCACTTGCAGTGGATTGGATGTGTAGGGAGAAGGGGAAaaaaaaaaagaactaggagtaaaaggt
Downstream sequence
gaaagatttatatgatattaccttgactgtgggtatcatccgtgtttgtatatatccaaagccatcaaattgaacatattaaatatgtgcaatattttat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate