Basic Information
VIS ID
TVIS10009143
Fusion event
HBV-chr18 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1819
Orient
+
Integrated sequence
TTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGC| |AACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTA
Host Sequence
Chromosome
chr18
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
71071352/73404117 (Hg38)
End
71071352/73404117 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1-2/Upstream/550735;
Nearest TSS
ENST00000575820/Upstream/535077; ENST00000581467/Downstream/311373;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/534481, chr18-CpG: 97/Downstream/743203
Nearby gene
LINC02582(-54228) ; FBXO15(+669236) ;
Upstream sequence
cataaaatctgaatttcctcacgtctcccaagtttcccagcatgcttggatagatgtgaacggcttttagtccccagtggggactgggacacctcagcca
Downstream sequence
aagttttagtcatctttctgtttaaagccagagaggaagggggaaggatcagggcaaagaggaaagaaaggccctgtAAACAGACTGTTGTGGTGCAGCT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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