Basic Information
VIS ID
TVIS10009144
Fusion event
HBV-LOC101927400 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1822
Orient
-
Integrated sequence
GTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAAC| |TTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAA
Host Sequence
Chromosome
chr2
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
114172430/113414853 (Hg38)
End
114172430/113414853 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2B
Target gene
LOC101927400
Nearest miRNA
hsa-mir-1285-2/Upstream/1643719; hsa-mir-10b/Downstream/168106;
Nearest TSS
ENST00000437798/Upstream/8457; ENST00000422178/Downstream/9642;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/89655, chr2-CpG: 39/Downstream/22735
Nearby gene
PAX8(-135932) ; CBWD2(+22838) ;
Upstream sequence
agatcaagaaagaggacattactagcttccagatgccctatcatgtggcttcccagtttagttccctcaaggataatgaatattctgactattaatgtca
Downstream sequence
tagatcagttttatcttcttttgaagtttatgtaagtggaatcttttctgtctggtcaatatcatgtttctgagattcatctatattgttgcctttagtt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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