Basic Information
VIS ID
TVIS10009147
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1780
Orient
-
Integrated sequence
AATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGA| |GGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCT
Host Sequence
Chromosome
chr2
Cytoband
q31.2
Reference genome
GRCh37/hg19
Start
178461846/177597118 (Hg38)
End
178461846/177597118 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA2G
Nearest miRNA
hsa-mir-10b/Upstream/283236; hsa-mir-1244-1/Downstream/2263718;
Nearest TSS
ENST00000437798/Upstream/44104; ENST00000357045/Downstream/5971;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/43885, chr2-CpG: 59/Downstream/21387
Nearby gene
TTC30B(-44322) ; TTC30A(+17180) ;
Upstream sequence
GTCTATTAAGAATGAAACACCACCCTGGAGGCTACAACCTTTACAAGGTCTGTGTTTCTTCTCCAAAAAATAAAAAGAACAAAGTCACCACTCTCCTCTC
Downstream sequence
TCAACTGGAGGAAAACTCAGTAGAAACTCAACACTCTTTTTCAGTGAGAAATACCTGATGTCATATATTTTGTTTAATAAAGACTGAATTGGCTGTACAC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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