Basic Information
VIS ID
TVIS10009150
Fusion event
HBV-LOC100286922 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1790
Orient
+
Integrated sequence
ACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGC| |ATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGG
Host Sequence
Chromosome
chr2
Cytoband
q37.1
Reference genome
GRCh37/hg19
Start
234663319/233754673 (Hg38)
End
234663319/233754673 (Hg38)
Orient
-
Location type
ncRNA_exonic
Target gene
LOC100286922
Nearest miRNA
hsa-mir-10b/Upstream/1204100; hsa-mir-149/Downstream/3756258;
Nearest TSS
ENST00000437798/Upstream/25565; ENST00000360418/Downstream/5575;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/10599, chr2-CpG: 41/Downstream/276
Upstream sequence
TGCCGTTTATTATGAAGGACTTTAACTCAACTCTCCATCTTCCTCCACTTCCACCCTTTCTTGGCCATTCTCAATGATTCTCTTGGTGGTGATTTTTTTA
Downstream sequence
CCATCAACTATTTCAGTGGAAGTCGACATGGACTTGAAGCTGCCTGTCCCATCACTACCGTAGGACATGCAGAAGGAAGAAAGGCCCCCACTTCCCAGGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate