Basic Information
VIS ID
TVIS10009154
Fusion event
HBV-chr20 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2000
Orient
+
Integrated sequence
GCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATAC| |CGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATG
Host Sequence
Chromosome
chr20
Cytoband
q11.23
Reference genome
GRCh37/hg19
Start
37093428/38464785 (Hg38)
End
37093428/38464785 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-103a-2/Upstream/3010688; hsa-mir-1-1/Downstream/51778;
Nearest TSS
ENST00000382410/Upstream/45583; ENST00000495949/Downstream/8031;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/17574, chr20-CpG: 68/Downstream/7743
Nearby gene
SNHG11(-13864) ; RALGAPB(+8058) ;
Upstream sequence
gccagcatggtgaaaccccatctctactaaaaatacaaaacattagccggacatggtggcacacacctgtaattccagctactcaggaagctgaggcagg
Downstream sequence
agaatagcttgaacccaggaggcgaaagtttcagtcagccaaaatcacaccactgcactccagcctgggcaacagagcaagactctgtctccaaaaaaaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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