Basic Information
VIS ID
TVIS10009155
Fusion event
HBV-chr21 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1792
Orient
-
Integrated sequence
CGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCAT| |AAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTG
Host Sequence
Chromosome
chr21
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
17021783/15649464 (Hg38)
End
17021783/15649464 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA21A
Nearest miRNA
hsa-mir-10396a/Upstream/1925190; hsa-let-7c/Downstream/889625;
Nearest TSS
ENST00000624081/Upstream/22122; ENST00000464435/Downstream/80561;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/583921, chr21-CpG: 123/Downstream/80070
Nearby gene
NRIP1(-584657) ; USP25(+80713) ;
Upstream sequence
CTAAGTATTTTGAGAGTTATAGATTATTGAAGCAAAATTATTAATTGAGCACCAAGCTCTGCCATTGCCTCCAGGAAGCTACAGAGAACATTATTACTTG
Downstream sequence
TAACCTAATGAGCCTTCAGAAATCAGTAACTAATCATGTTCATGACTTGCTATAGTTATTAGCATTAAACATGGATTAGACTAATTTTTAGTATTATACA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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