Basic Information
VIS ID
TVIS10009156
Fusion event
HBV-chr21 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2105
Orient
+
Integrated sequence
CAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCT| |AGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTG
Host Sequence
Chromosome
chr21
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
17021796/15649477 (Hg38)
End
17021796/15649477 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA21A
Nearest miRNA
hsa-mir-10396a/Upstream/1925203; hsa-let-7c/Downstream/889612;
Nearest TSS
ENST00000624081/Upstream/22135; ENST00000464435/Downstream/80548;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/583934, chr21-CpG: 123/Downstream/80057
Nearby gene
NRIP1(-584670) ; USP25(+80700) ;
Upstream sequence
GAGTTATAGATTATTGAAGCAAAATTATTAATTGAGCACCAAGCTCTGCCATTGCCTCCAGGAAGCTACAGAGAACATTATTACTTGTAACCTAATGAGC
Downstream sequence
CTTCAGAAATCAGTAACTAATCATGTTCATGACTTGCTATAGTTATTAGCATTAAACATGGATTAGACTAATTTTTAGTATTATACATGGGTGGGATTTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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