Basic Information
VIS ID
TVIS10009161
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1820
Orient
-
Integrated sequence
TTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCA| |ACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTAT
Host Sequence
Chromosome
chr3
Cytoband
q13.12
Reference genome
GRCh37/hg19
Start
106721872/107003025 (Hg38)
End
106721872/107003025 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7g/Upstream/3478909; hsa-mir-12124/Downstream/2599803;
Nearest TSS
ENST00000440867/Upstream/1133473; ENST00000473550/Downstream/126966;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/1133651, chr3-CpG: 49/Downstream/237537
Nearby gene
CBLB(-1133985) ; LINC00882(+106765) ;
Nearest cancer related gene
CBLB(OG, -1133985) ;
Upstream sequence
TGTGACCAAATAAAAGTTACTGTGAACAGCCAAACTAAAATGGATTCCAAAATATTTAATTTGAAGGAACTCATTCTTGAAAATTTAGCTTCCTTATAAA
Downstream sequence
AATTCACATCGATGTTTTAAACCCTAACATATTATTTCTCTAATAGCCATATTGTAAAGGTAAATCTGTGGTTTCCatttctatttcagaaagacagaaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate