Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10009164
Fusion event
HBV-PLCL2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|
Start
1850
Orient
+
Integrated sequence
GAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTG| |TTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTC
Host Sequence
Chromosome
chr3
Cytoband
p24.3
Reference genome
Start
End
16983902/16942410 (Hg38)
Orient
-
Location type
Intronic
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-12127/Upstream/9150; hsa-let-7g/Downstream/2372438;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/57060, chr3-CpG: 58/Downstream/800160
Upstream sequence
ACAAAATAAAGACAGAACTCAGCACTATTTATATCACACCAGAACTGACTCAGCGCCATTGCCCATTTAACTCACTTGTCTTGCTATTTGGAGATGTTCT
Downstream sequence
AACTTCCCATTACCTTTTCCTGCTGGCAGGCTAGAAAACAAGCCCTGAAAGAGAAGGAGTGCGTCCTTCCCTCCCAGGTGCTCACTGATGGATTTTCAGC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.