Basic Information
VIS ID
TVIS10009173
Fusion event
HBV-LOC107983963 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2252
Orient
+
Integrated sequence
TAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGA| |GTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGA
Host Sequence
Chromosome
chr4
Cytoband
q35.2
Reference genome
GRCh37/hg19
Start
188612963/187691809 (Hg38)
End
188612963/187691809 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC107983963
Nearest miRNA
hsa-mir-12113/Upstream/2753369;
Nearest TSS
ENST00000502981/Upstream/19168; ENST00000509524/Downstream/303962;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/78050, chr4-CpG: 45/Downstream/414646
Nearby gene
LOC339975(-186196) ; ZFP42(+303962) ;
Upstream sequence
TAGTTACTGCTGAACATCTTGACTATTTAAATAAATCACTATTTTTTCCCTAACCTTGTCCAGATTTCTAAAACTCAGTTACTCTCCTAACCAGTCTACT
Downstream sequence
TATGCTTGAAAAACTCCGTTTTTCGGCTTAGTTGAATTACTCTGAACATAAAGTAGAAAGCGAAGATAGAGCCAGATGGTATTTTATTTTGACTATTACA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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