VISDB Viral Integration Site DataBase

VIS ID

TVIS10009174

Fusion event

HBV-TBC1D1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

1990

Orient

-

Integrated sequence

TGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATC| |TTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGG

Chromosome

chr4

Cytoband

p14

Reference genome

Start

End

37969896/37968275 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-125b-5p ; hsa-mir-193b-3p ; hsa-mir-7-1-3p ; hsa-mir-125a-5p ; hsa-mir-299-5p ; hsa-mir-548au-3p ; hsa-mir-449c-5p ; hsa-mir-34b-5p ; hsa-mir-2682-5p ; hsa-mir-3714

Nearest miRNA

hsa-mir-12113/Upstream/726284; hsa-mir-1243/Downstream/899757;

Nearest TSS

Nearest CpG islands

None/Target, chr4-CpG: 46/Upstream/76582, chr4-CpG: 98/Downstream/8806

Nearest cancer related gene

TBC1D1(OG, No orient, 0)

Upstream sequence

attccattccattccattccattccactcgtgttgattcccttccattccattccattccattccacttgtgttgattccattccgttcctttcgattgc

Downstream sequence

TCTTCTTGTCTCCTCTGGAGTTGCAAGTTCAGGGGTTCCCTTTTACCCTGCAGTCTTCTTAGTATTTCTGGTGGGACTGCAGCCAGCTATTAATTTTGCA