VISDB Viral Integration Site DataBase

VIS ID

TVIS10009177

Fusion event

HBV-MAPK10 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1817

Orient

-

Integrated sequence

TGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCAT| |GCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCT

Chromosome

chr4

Cytoband

q21.3

Reference genome

Start

End

87137700/86216547 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-221-3p ; hsa-mir-574-5p ; hsa-mir-5572 ; hsa-mir-4260 ; hsa-mir-450a-2-3p ; hsa-mir-6855-5p ; hsa-mir-3170 ; hsa-mir-6819-5p ; hsa-mir-6812-5p ; hsa-mir-6737-5p ; hsa-mir-6867-5p ; hsa-mir-3650 ; hsa-mir-4455 ; hsa-mir-6747-5p ; hsa-mir-608 ; hsa-mir-4651 ; hsa-mir-4664-5p ; hsa-mir-342-5p ; hsa-mir-5002-5p ; hsa-mir-499a-5p ; hsa-mir-208b-3p ; hsa-mir-208a-3p ; hsa-mir-3152-3p ; hsa-mir-641 ; hsa-mir-3617-5p

Nearest miRNA

hsa-mir-12113/Upstream/494014; hsa-mir-1243/Downstream/325935;

Nearest TSS

Nearest CpG islands

None/Target, chr4-CpG: 46/Upstream/740731, chr4-CpG: 77/Downstream/377483

Nearest cancer related gene

MAPK10(TSG, No orient, 0)

Upstream sequence

ctcgtgttgattcccttccattccattccattccattccattccattccattccattccacttgggttgattccattccgttcctttcgattgcattcca

Downstream sequence

aacttctactaaagaagtaatcaaatatctatattttaatccataagattaatccctaataatgtttaccacagcattatttataataaaataatagaaa