Basic Information
VIS ID
TVIS10009180
Fusion event
HBV-LOC105374655 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2042
Orient
+
Integrated sequence
AGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCA| |TTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCG
Host Sequence
Chromosome
chr5
Cytoband
p15.2
Reference genome
GRCh37/hg19
Start
12390982/12390870 (Hg38)
End
12390982/12390870 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105374655
Nearest miRNA
hsa-mir-10397/Upstream/1912725; hsa-mir-103a-1/Downstream/2435059;
Nearest TSS
ENST00000502646/Upstream/486827; ENST00000505877/Downstream/183767;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/486279, chr5-CpG: 46/Downstream/403990
Nearby gene
CTNND2(-486872) ; LINC01194(+183987) ;
Upstream sequence
GAAGGAGAGTGGTTAAAGAAAGGGGAAAATTATGTTTGCTGAATAGAAGGGTAGGAGAAGGTGGGAGGAGAAAAGGAGAGATTTTATGAGGTCAAAGAAC
Downstream sequence
taacagctgcagtagatttgaaggcatagctccatactcaaaaatgttaatgtttctgaaattaaacatatgaatatttatacaaaatatcacacataca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate