Basic Information
VIS ID
TVIS10009186
Fusion event
HBV-CEP57L1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1823
Orient
-
Integrated sequence
TTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACT| |TTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAA
Host Sequence
Chromosome
chr6
Cytoband
q21
Reference genome
GRCh37/hg19
Start
109449688/109128485 (Hg38)
End
109449688/109128485 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA6F
Target gene
CEP57L1
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-3187-3p ; hsa-mir-4435 ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-548s ; hsa-mir-23c ; hsa-mir-23b-3p ; hsa-mir-23a-3p ; hsa-mir-130a-5p ; hsa-mir-411-5p ; hsa-mir-6832-5p ; hsa-mir-4524a-3p ; hsa-mir-6823-5p ; hsa-mir-4717-3p ; hsa-mir-4781-3p ; hsa-mir-4524b-3p ; hsa-mir-129-5p ; hsa-mir-4776-3p ; hsa-mir-4715-3p ; hsa-mir-3064-3p ; hsa-mir-4252 ; hsa-mir-4330 ; hsa-mir-153-5p ; hsa-mir-10b-3p ; hsa-mir-6514-3p ; hsa-mir-7977 ; hsa-mir-3178 ; hsa-mir-5787 ; hsa-mir-4505 ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-6847-3p ; hsa-mir-6811-3p ; hsa-mir-214-5p ; hsa-mir-4486 ; hsa-mir-5693 ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-6516-5p ; hsa-mir-455-3p ; hsa-mir-7847-3p ; hsa-mir-6880-5p ; hsa-mir-6851-5p ; hsa-mir-3689d ; hsa-mir-6499-3p ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-6134 ; hsa-mir-4487 ; hsa-mir-558 ; hsa-mir-3160-3p ; hsa-mir-6761-5p ; hsa-mir-4324
Nearest miRNA
hsa-mir-10398/Upstream/2344265; hsa-mir-1202/Downstream/9940562;
Nearest TSS
ENST00000381078/Upstream/32923; ENST00000523174/Downstream/819;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/32941, chr6-CpG: 35/Downstream/161761
Upstream sequence
TTAGGTGGGAGGCTTCTGTTAAAGGGCAAGGTGTCCAATCTCCGTAGTCAGATCCAAGTTTGACTCTGGCCTTTTCCTCTTCCCCGCCATGCAGTTGTTA
Downstream sequence
tgtccatctgcctataatttcttcctccttttgtctgttcaccttaaagccgtctgaatgaacttgtcaaaatgcaaacctggtcatgttattccctttt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate