VISDB Viral Integration Site DataBase

VIS ID

TVIS10009187

Fusion event

HBV-MFSD4B integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

1930

Orient

+

Integrated sequence

CTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTG| |GAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGA

Chromosome

chr6

Cytoband

q21

Reference genome

Start

End

111593818/111272615 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-373-3p ; hsa-mir-17-5p ; hsa-mir-6864-3p ; hsa-mir-3672 ; hsa-mir-4524a-3p ; hsa-mir-4742-3p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-365b-5p ; hsa-mir-365a-5p ; hsa-mir-8052 ; hsa-mir-3199 ; hsa-mir-6778-3p ; hsa-mir-4258 ; hsa-mir-4740-3p ; hsa-mir-6715b-5p ; hsa-mir-4269 ; hsa-mir-4438 ; hsa-mir-5698 ; hsa-mir-891a-3p ; hsa-mir-143-5p ; hsa-mir-6879-3p ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-593-5p ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-6499-3p ; hsa-mir-767-5p ; hsa-mir-215-3p ; hsa-mir-6773-3p ; hsa-mir-4638-5p ; hsa-mir-1307-3p ; hsa-mir-6741-3p ; hsa-mir-5693 ; hsa-mir-500b-3p ; hsa-mir-6812-3p

Nearest miRNA

hsa-mir-10398/Upstream/4488395; hsa-mir-1202/Downstream/7796432;

Nearest TSS

Nearest CpG islands

None/Target, chr6-CpG: 120/Upstream/13024, chr6-CpG: 181/Downstream/209738

Nearby gene

MFSD4B(-3557) ; REV3L(+26416) ;

Upstream sequence

aattacagattagtttgcattttctggaatttatacaagtcaaatcacacagtttatattcttttgtctggtttctttccttccacacaatgattttgaa

Downstream sequence

attctcattcctcagccacccaagtagctgggattacaggcatgtgtcaccattcctggctaatttttgtatttttagtagagatggggttttaccatgt