Basic Information
VIS ID
TVIS10009198
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1777
Orient
-
Integrated sequence
AGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTA| |GGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAA
Host Sequence
Chromosome
chr7
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
93754484/94125172 (Hg38)
End
93754484/94125172 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10525/Upstream/408167; hsa-mir-10399/Downstream/2094490;
Nearest TSS
ENST00000635602/Upstream/48015; ENST00000488298/Downstream/267024;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/120574, chr7-CpG: 98/Downstream/384538
Nearby gene
BET1(-120794) ; COL1A2(+269389) ;
Upstream sequence
cataaacaactacatgtaagttattagttattattTTCATAATAGGGTATTATTCTTTTGATCGGGATAGGGAGAAGAAGCACCCGGAAGAACATGTAGA
Downstream sequence
AGTGGACCTATGCCTGCAAAATGACTTGTCCTTTGTTGTACCTAACCTACTCCTTCTAAATGACTAAGTTAACTCTTTAATAATTACCAAAGCTGGCAAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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