MRPL13 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10009201
Fusion event
HBV-MRPL13 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2204
Orient
+
Integrated sequence
TAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTT| |GTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCA
Host Sequence
Chromosome
chr8
Cytoband
q24.12
Reference genome
GRCh37/hg19
Start
121448432/120436192 (Hg38)
End
121448432/120436192 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA8C ; FRA8E
Target gene
MRPL13
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-20a-5p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-12123/Upstream/1110927; hsa-mir-10400/Downstream/2779596;
Nearest TSS
ENST00000518652/Upstream/20113; ENST00000456899/Downstream/8900;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/310653, chr8-CpG: 24/Downstream/8921
Upstream sequence
attaacagagttttggaaactcctccaggtgactccagtgcgtggtcaggtttgggaaccacAGGTCTGGAAAAAATGATTAAATTTAATCTTTCTGTGt
Downstream sequence
caagagaaatgaaactgctgtgctatacagtaagctcatgtttagttttagaagaaactgccatattcttttccagagttgctgtaccatgttacatttc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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