Basic Information
VIS ID
TVIS10009205
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1754
Orient
+
Integrated sequence
CATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGA| |TTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCA
Host Sequence
Chromosome
chr8
Cytoband
p12
Reference genome
GRCh37/hg19
Start
35825045/35967527 (Hg38)
End
35825045/35967527 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-124-1/Upstream/6010179; hsa-mir-10400/Downstream/5303521;
Nearest TSS
ENST00000518652/Upstream/105020; ENST00000522417/Downstream/126482;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/730934, chr8-CpG: 351/Downstream/1726899
Nearby gene
UNC5D(-172864) ; KCNU1(+816797) ;
Nearest cancer related gene
UNC5D(TSG, -172864) ;
Upstream sequence
caggaatttttgtgtttgtttgtttgtttttttttttttttgagacggggtcccgctctttagcccaggccggattgcagtggcacaatcttggctcact
Downstream sequence
TTCATCTCCTGTGTTTTCAGGTACCCagtacttgtcttatcacagacatcaaaataggcattgtagttatctatttgttgattttaattatccattattc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate