Basic Information
VIS ID
TVIS10009208
Fusion event
HBV-FRG1HP integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1822
Orient
-
Integrated sequence
GTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAAC| |TTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAA
Host Sequence
Chromosome
chr9
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
68748149/41013912 (Hg38)
End
68748149/41013912 (Hg38)
Orient
-
Location type
ncRNA_exonic
Target gene
FRG1HP
Nearest miRNA
hsa-mir-101-2/Upstream/84820; hsa-let-7a-1/Downstream/219843;
Nearest TSS
ENST00000422679/Upstream/224636; ENST00000613309/Downstream/59798;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/21177, chr9-CpG: 83/Downstream/59975
Upstream sequence
aaccccgtctctactaaaaatacaaaaaattagccgggcgcggtggcgggcgcctgtagtcccagctactcgggaggctgaggcaggagaatggcgtgaa
Downstream sequence
tatgacattaatagtcagaatattcattatccttgagggaactaaactgggaagccacatgatagggcatctggaagctagtaatgtcctctttcttgat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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