Basic Information
VIS ID
TVIS10009213
Fusion event
HBV-SWT1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1637
Orient
+
Integrated sequence
TTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAA| |TATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGA
Host Sequence
Chromosome
chr1
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
185244982/185275850 (Hg38)
End
185244982/185275850 (Hg38)
Orient
+
Location type
Intronic
Target gene
SWT1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-19b-3p
Nearest miRNA
hsa-mir-101-1/Upstream/4837460; hsa-mir-1182/Downstream/7440478;
Nearest TSS
ENST00000473358/Upstream/118368; ENST00000609881/Downstream/25068;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/118277, chr1-CpG: 114/Downstream/40347
Upstream sequence
CTATGAAAACATTGAAGAAAGTCATGGAATTTTTGCCAATAAGCAATACATTGAATCATATAGAAGACTTTTATGATAAGAATCTTTAAATTAGTAGTAA
Downstream sequence
TTAAATTAGGGGGTATCATTCTTCCCCACCAAAAAATGCATGCCAGCTAGCAACACTTAGAAATGTTTTTTAAGTAAATTGAATAGAAATTAGCCTTACT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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