VISDB Viral Integration Site DataBase

VIS ID

TVIS10009239

Fusion event

HBV-CCAR1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1803

Orient

-

Integrated sequence

CATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTG| |CGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCA

Chromosome

chr10

Cytoband

q21.3

Reference genome

Start

End

70492708/68732951 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-24-3p ; hsa-mir-186-5p ; hsa-mir-92a-3p ; hsa-mir-1254 ; hsa-mir-29a-5p ; hsa-mir-548av-3p ; hsa-mir-548g-3p ; hsa-mir-8055

Nearest miRNA

hsa-mir-1265/Upstream/1329541; hsa-mir-107/Downstream/3057796;

Nearest TSS

Nearest CpG islands

None/Target, chr10-CpG: 68/Upstream/11110, chr10-CpG: 185/Downstream/94209

Nearest cancer related gene

CCAR1(TSG, No orient, 0)

Upstream sequence

gagttcaaggctgcagtgagctaagattgcaccaccgcattccagcctgggtaacagtgtgactgcatctctgaaaaaataataatagaaCCTGTGCCCT

Downstream sequence

ACATTTTGATGCACTATTTTTTCTGTATTCTCATTGCGGTTAACCTCATTTTGAATTAATACTGGTGTTAAGATATTCCCCACGTCTATTTAAATTCACT