VISDB Viral Integration Site DataBase

VIS ID

TVIS10009240

Fusion event

HBV-CCAR1 integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|Polymerase|

Start

2340

Orient

+

Integrated sequence

AACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACT| |ACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGG

Chromosome

chr10

Cytoband

q21.3

Reference genome

Start

End

70492716/68732959 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-24-3p ; hsa-mir-186-5p ; hsa-mir-92a-3p ; hsa-mir-1254 ; hsa-mir-29a-5p ; hsa-mir-548av-3p ; hsa-mir-548g-3p ; hsa-mir-8055

Nearest miRNA

hsa-mir-1265/Upstream/1329549; hsa-mir-107/Downstream/3057788;

Nearest TSS

Nearest CpG islands

None/Target, chr10-CpG: 68/Upstream/11118, chr10-CpG: 185/Downstream/94201

Nearest cancer related gene

CCAR1(TSG, No orient, 0)

Upstream sequence

ggctgcagtgagctaagattgcaccaccgcattccagcctgggtaacagtgtgactgcatctctgaaaaaataataatagaaCCTGTGCCCTACATTTTG

Downstream sequence

ATGCACTATTTTTTCTGTATTCTCATTGCGGTTAACCTCATTTTGAATTAATACTGGTGTTAAGATATTCCCCACGTCTATTTAAATTCACTTTGTTGGT