VISDB Viral Integration Site DataBase

VIS ID

TVIS10009242

Fusion event

HBV-LUZP2 integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|

Start

1840

Orient

+

Integrated sequence

GTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAA| |TCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGT

Chromosome

chr11

Cytoband

p14.3

Reference genome

Start

End

24654658/24633112 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-653-5p ; hsa-mir-5585-3p ; hsa-mir-374b-5p ; hsa-mir-374a-5p ; hsa-mir-205-3p ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-369-3p ; hsa-mir-5590-3p ; hsa-mir-142-5p ; hsa-mir-652-5p ; hsa-mir-4796-3p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p ; hsa-mir-548ah-5p ; hsa-mir-3609 ; hsa-mir-548s ; hsa-mir-3165 ; hsa-mir-3926 ; hsa-mir-4786-5p ; hsa-mir-3190-5p ; hsa-mir-7162-3p ; hsa-mir-6078 ; hsa-mir-544b ; hsa-mir-6849-3p ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4768-3p ; hsa-mir-340-3p ; hsa-mir-548c-3p ; hsa-mir-6771-3p ; hsa-mir-6827-3p

Nearest miRNA

hsa-mir-210/Upstream/1213922; hsa-let-7a-2/Downstream/2881858;

Nearest TSS

Nearest CpG islands

None/Target, chr11-CpG: 30/Upstream/135920, chr11-CpG: 29/Downstream/1698878

Upstream sequence

ATGATAGGATATAGAAAGGAAATCTGAGCAACAGGAGTAAAAGATTATCTTGTTTTGATGTGAATTGCCTTTTCTAGTCTGGGAGATTTTCTTGTTGCCT

Downstream sequence

TCATGATGACCATATGTAAAATTACCTTCATATGTATGTGGCATTTTTCCACATTTATTTACACTTATCTTGCACTCACATTCAAAGGCACTCAGGAGTA