Basic Information
VIS ID
TVIS10009246
Fusion event
HBV-DIO2-AS1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1828
Orient
-
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT
Host Sequence
Chromosome
chr14
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
80728588/80262245 (Hg38)
End
80728588/80262245 (Hg38)
Orient
+
Location type
ncRNA_intronic
Target gene
DIO2-AS1
Nearest miRNA
hsa-mir-1260a/Upstream/2995955; hsa-mir-1185-1/Downstream/13685981;
Nearest TSS
ENST00000550708/Upstream/31191; ENST00000557096/Downstream/53593;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/400257, chr14-CpG: 29/Downstream/679121
Upstream sequence
tttagtagatgaggtttcactatgttgccaaggctggtcatgaactcctgggctcaagcaatcctctgccttggcctcccaaagtgctggaattataagt
Downstream sequence
gtgagctatcatgcctagccAAAATCCTAAAGATTCTTTAGCACTTAGCTGAATTGTCACTTCTAGAAAGCTGTAGAAAGCCTAAATGTCTCTCTCCTAC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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