Basic Information
VIS ID
TVIS10009250
Fusion event
HBV-DPH6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1637
Orient
-
Integrated sequence
TTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAA| |TATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGA
Host Sequence
Chromosome
chr15
Cytoband
q14
Reference genome
GRCh37/hg19
Start
35659215/35367014 (Hg38)
End
35659215/35367014 (Hg38)
Orient
+
Location type
Intronic
Target gene
DPH6
Nearest miRNA
hsa-mir-1233-1/Upstream/838643; hsa-mir-10393/Downstream/5242;
Nearest TSS
ENST00000557528/Upstream/197316; ENST00000560866/Downstream/43837;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/244775, chr15-CpG: 56/Downstream/178911
Nearby gene
ANP32AP1(-128951) ; DPH6(+3955) ;
Upstream sequence
GTTTTTTAAACAGAGTAGGTATTCAAGATACATGCTGGATTGAAGAGAAAAATAAAAACACAGAGATGGCTAAACATTATAAAGTTTTTCAAGGCATTTG
Downstream sequence
ATGATATATCTCAAATAAAGCAAAATAAAATGAAAGAGCCAAGAATGGGCTGTAAGACTGATGATGTTTTTAAAAGTGACAACTTTTAAAAGTGTGTGCt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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