Basic Information
VIS ID
TVIS10009252
Fusion event
HBV-chr16 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
707
Orient
+
Integrated sequence
CCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGT| |AGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCATCTTGAGTCCCTTTTTACCGCTGTTACCA
Host Sequence
Chromosome
chr16
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
47898814/47864903 (Hg38)
End
47898814/47864903 (Hg38)
Orient
-
Location type
Intronic
Target gene
LINC02133 ; LINC02192
Nearest miRNA
hsa-mir-1225/Upstream/13701230; hsa-mir-11401/Downstream/2427713;
Nearest TSS
ENST00000527434/Upstream/6324; ENST00000562980/Downstream/22227;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/403607, chr16-CpG: 31/Downstream/379518
Nearby gene
PHKB(-163380) ; ABCC12(+218070) ;
Upstream sequence
ctccccatgtgatagtctgaaatatggcctcgtgggaagggaaagacctgaccgtcccccagcccaacacccgtaaagggtctgtgctgaggaggattag
Downstream sequence
taaaagaggaaggaatgcctcttgcagttgagacaagaggaaggcatctgtctcctgcctgtccctgggcaatggaatgtctcggtataaaacccgattg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate