Basic Information
VIS ID
TVIS10009257
Fusion event
HBV-chr20 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
629
Orient
-
Integrated sequence
TGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTT| |CGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGG
Host Sequence
Chromosome
chr20
Cytoband
q13.13
Reference genome
GRCh37/hg19
Start
49118504/50501967 (Hg38)
End
49118504/50501967 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-103a-2/Upstream/638014; hsa-mir-1-1/Downstream/83819;
Nearest TSS
ENST00000382410/Upstream/180625; ENST00000541713/Downstream/8354;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/158131, chr20-CpG: 84/Downstream/8113
Nearby gene
LINC01270(-187048) ; PTPN1(+8387) ;
Nearest cancer related gene
PTPN1(TSG, +8387) ;
Upstream sequence
atccctgcattctgtaaaagatggaaaaccaaggattggagagggtaaggaacttgcccaagggcacaTGAGCCCAATTCAGCCTAATTCCAGAACCCAC
Downstream sequence
ACCCAGAACCACCATGTGTACAGTGAAAGTGCCCCCGCAAGCCTCAGCCCTGCAAACTAGAGTGTGGAGGATGTTGTAGGGGCCTCTGGAAACCCTCCCC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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