Basic Information
VIS ID
TVIS10009258
Fusion event
HBV-LOC101930100 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
704
Orient
-
Integrated sequence
TTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTT| |CGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCATCTTGAGTCCCTTTTTACCGCTGTTA
Host Sequence
Chromosome
chr21
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
10164472/9325639 (Hg38)
End
10164472/9325639 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC101930100
Nearest miRNA
hsa-mir-10396a/Upstream/337974; hsa-let-7c/Downstream/4080745;
Nearest TSS
ENST00000624081/Upstream/272; ENST00000624226/Downstream/484084;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/157, chr21-CpG: 29/Downstream/254242
Nearby gene
TEKT4P2(-195879) ; TPTE(+742271) ;
Upstream sequence
AGTGAAGTTTCTGGTTCCCTCCTTCACTGTGTGACCTGCCTAGTCCTCCTGGGTCGCATTTACAGAAGTTTATACGAGACCTAGTTTCCAGGGAAGAACT
Downstream sequence
CACTGATTCCGCGAGGGAGATGGCTTAATGGATGATGGTCGTCAGCCTTAAGGATACTTCAGTCTTAACTGTGTGTTACAAAGTTTGAAAGGGAGGGTTC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate